The LCSB is accelerating biomedical research by closing the link between systems biology and medical research. Collaboration between biologists, medical doctors, computer scientists, physicists and mathematicians is offering new insights in complex systems like cells, organs, and organisms. These insights are essential for understanding principal mechanisms of disease pathogenesis and for developing new tools in diagnostics and therapy.
Neurodegenerative diseases like Parkinson’s disease, metabolomics and disease network analysis are in the focus of LCSB’s research. Within Luxembourg the LCSB is building up strong partnerships with all major biological and medical research units. Key strategic partnership has been set-up with the ISB in Seattle. This cooperation is enabling a rapid scientific evolution. The LCSB fosters collaboration with industrial partners and will be a focal point for developing a knowledge based economy in Luxembourg.
Within the recently established National Centre of Excellence in Research on Parkinson’s Disease, Luxembourg has set up the following platform to build up a Parkinson’s patient cohort:
- The Epidemiology and Statistics platform is established by the LIH and will support the recruitment of healthy controls, data acquisition and communication with the consortium.
- The Clinical platform is established by the CHL together with other clinical facilities in Luxembourg and will support the broad recruitment of patients with parkinsonism, clinical assessments as well as sample and data collection.
- The Biobanking platform is established by the IBBL and with the help of the LCSB will support sample collection, processing, analysis, storage and managemen
- The Data and Computation platform is established by the LCSB and supports the cohort with its large infrastructure for integration, curation and analysis of multidimensional data. It will also establish secure and anonymised data. Well-grounded machine learning and computational modeling approaches will enable data analysis and interpretation.
- Biggest academic high-performance computing platform in Luxembourg with more than 5000 compute cores and over 3 PetaByte of data storage.
- Comprehensive bioinformatics analysis platform with more than 100 pre-installed bioinformatics tools and hundreds of public domain databases. Additional tools for visualisation and in depth statistical analysis like Cytoscape, PhenoTimer for longitudinal data and in house developed analytics are available as part of a large scale production environment.
- Development of a comprehensive interactive disease map for Parkinson’s disease
- Development of bioinformatics software tools to investigate pathway deregulations in functional genomics datasets using a graph based statistic and molecular network data (EnrichNet), to identify discriminative pathway signatures for diagnostic sample classification (PathVar), and to score candidate disease genes in the network neighborhood of disease associated pathways (PathExpand).
- Data management, curation and mining of large and heterogeneous datasets
- Clinical and bio-banking data capture and management projects
- Computer-aided planning and analysis of DBS procedures as well as analysis of potential feedback mechanisms for DBS